Striker Wayne Rooney has been ruled out of a re-shuffled England side to face Spain in Wednesday's friendly.

England manager Steve McClaren said Rooney, who picked up a back injury in Manchester United's 4-0 win at Tottenham Hotspur on Sunday, had not recovered in time and would be replaced by Peter Crouch.

Bigger changes are in store at the back, largely due to injury absences, with Phil Neville stepping in after England lost both their left backs, Ashley Cole and Wayne Bridge.

Captain John Terry's long-term injury absence means he will be rested and his place alongside Rio Ferdinand handed to Jonathan Woodgate, with Gary Neville at right back.

The game is being used by both sides as preparation for next month's Euro 2008 qualifiers, though injuries have made it a selection headache for McClaren.

England's last game against Spain was a 1-0 defeat in Madrid in 2004.

Editor: Donald